Recent advances in bioMEMS and microfluidics devices are set to foster a brave new world of nano-biology. As the field of bioMEMS and the development of microfluidic devices continue to expand, so too does the physical and geometric complexity of these devices.
Developing cutting-edge technologies requires cutting-edge tools. Unfortunately, most computational fluid dynamics (CFD) tools on the market were designed for either aircraft or automobiles, or for flow in pipes. Designing a bioMEMS chip is a different animal than designing plumbing. So why use code that is not optimized for bioMEMS and microfluidics?
Multiphysics and chemistry along with Microfluidics
We created a full 3D Navier-Stokes solver optimized for microfluidic applications from the ground up. Simultaneously, we went way beyond the existing code bases by adding support for electrokinetic phenomena, Red-Ox reactions, acids, bases, ampholytes and fluid structure interaction.
There was more to come. We then added advanced visualization algorithms to look at cross-sectional profiles, velocity vectors and transient results. Our code base is not only faster at solving microfludics problems but is the only tool for problems ranging from electrophoresis to isoelectric focusing. This module is created specifically for real-world bioMEMS.
Our Microfluidics module is a first to the market multi-block algorithm with an unparalleled feature set. It allows you to simultaneously solve for:
• Fluid flow and fluid dynamics
• Electrodynamics (time varying or constant electric fields)
• Electrokinetics
• Stochiometry and reaction kinetics (acids, bases, ampholytes, multi-valent analytes)
• Mass transport
• Heat transfer
• Electrochemistry
• Fluid structure interaction
• Particulates such as DNA, microspheres for dielectrophoresis and separations
Dr. Vijay Mohan of BigTec, a company developing micro-scale assays for disease detection confirmed, “We used IntelliSuite’s microfluidics module for characterizing flow velocities, pressure distributions and mass transport phenomenon. It is stable, fast and simple to use, models can be modified and re-analyzed with just a few clicks. The exemplary performance of its tools resulted in accurate device simulations.”
Applications
BioMEMS - Lab-on-a-Chip/ Micro Total Analysis Systems (µTAS)
Potentiaostatic & Galvenostatic Applications
Capillary Electroseparation Methods
Electroosmotic flow
Electrohydrodynamics
µ-Capillary Zone Electrophoresis (µCZE)
Dielectrophoresis
Flow cytometry
µ-Capillary Iso-electric Focusing (µCIEF)
Proteomics on a chip
µ-Capillary Isotachophoresis (µCI)
µ-Mixers
T-Sensors
Passive mixing in serpentine channels
Reaction Chambers
Drug Delivery
BioMEMS - Array Devices
DNA Hybridization Chips
Diffusion directed
Electric field directed
Protein Chips
Protein patterning
MEMS
Squeeze-Film Damping
MicroValves
Fluid-membrane interaction
Valve actuation, etc.
Future Applications
Coupled µ-CIEF (mass spectrometry for proteomics)
Software highlights
Geometry Creation & Meshing
Poweful, easy-to-use builder
Structured bodyfitted-coordinate mesh
Computationally efficient
Flexible mesh generation for complex geometries
Flexible, hexahedral finite element mesh for structural interaction
µfluidic Solvers
Multi-block finite volume solver
domain decomposition technique
appropriate for open/closed boundary flow
multi-physics transport conservation scheme
fast convergence for complex geometries
Finite element solver
fluid-structure interaction
deformable boundary tracking
Advanced Graphical User Interface for Pre- & Post- Processing
IntelliSuite, Total MEMS Solutions, CAD for MEMS, MEMaterial, AnisE, are registered trademarks of IntelliSense Software Corp. IntelliFAB, IntelliEtch, RECIPE, TEM, EMag, FABViewer, Clean Room, 3DBuilder, SYNPLE, EDA Linker, System Model Extractor, Fastfield Multiphysics, IntelliMask, IntelliMask Pro are trademarks of IntelliSense Software Corp.
